“Mechanisms. Models. Metaphors.”
The Mukherjee laboratory seeks to understand the biology of normal and malignant blood development, with a focus on understanding malignant and pre-malignant blood diseases such as Myelodysplastic Syndromes (MDS) and Acute Myelogenous Leukemia (AML). The role of the bone microenvironment is a longstanding interest, and the laboratory has showed that alterations in the microenvironment can initiate MDS. The laboratory was responsible for identifying skeletal stem cells (called Osteochondroreticular or OCR cells) and is currently studying how these stem cells can regenerate bone and cartilage after injury, and how they function during bone metastasis. Another interest involves studying mutations in RNA splicing factors, such as SF3B1 and SRSF2, that are found in MDS and AML.